what are your thoughts about how to solve the high DTI issue due to low income ($44,400) ?

also relatively high target purchase price ($350,000)? In general, what are some possible strategies that we should look into? 

Call them with the payment, ask her if she thinks she can afford it on her own. Talk them through the only options available, which is 1. Add another borrower ,soometimes you can also buy rates down to bring DTI down but this situation is unique and I think having another borrower would be good way to go about it. , or 2. Lower the purchase price.